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It is active both in cellsthat secrete protein by exocytosisand in cells that synthesize largeamountsofmembraneandmembrane-associatedproteinssuchasnervecells.

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Clinically,it may be difficult to differentiate between osteomyelitis and other reasons of bone paincaused by stress fracture, dental complication, vertebral collapse, or bone marrownecrosis [38]. Sero-tonin is formed by the hydroxylation and decarboxylationof tryptophan. The control caseswere given either vitamin E (800 IU/day) or were treated by a prescrip-tive, weight-reducing diet

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